Physicochemical behaviors of cationic gemini surfactant. Solubilization of drugs into micelles and its importance. In this paper, the discussion will be confined to the solubilization of water in wo micro emulsions. Ionic surfactants constitute a very important class of surfactants, both from an academic as well as from a commercial viewpoint.
Micro emulsions can exhibit a high solubilization capacity for both lipophilic and hydrophilic drugs, thus more drug can be loaded into the microemulsion, which increases the concentration gradient across the skin without depletion. Pdf enhancing solubilization in microemulsionsstate of the. In certain applications copolymer p123 e21p67e21 is dissolved in water. Buck laboratories of instrumental analysis and organic chemistry, university of technology, eindhoven, the netherlands. Physicochemical behaviors of cationic gemini surfactant 144. The addition of linker molecules enhances the microemulsion solubilization property, which increases the hydrophilicity and or the lipophilicity behavior of surfactants. To delivery of hydrophilic as well as lipophilic drug as drug carriers because of its improved drug solubilization capacity. Enter your mobile number or email address below and well send you a link to download the free kindle app.
Over 10 million scientific documents at your fingertips. Micellization, solubilization and microemulsions in. Theoretical modeling of micellization and solubilization. In some respects, microemulsions can be considered as smallscale. Semiempirical correlations such as cohesive energy ratio and hydrophilelipophile balance concepts, can be used to optimize emulsion and microemulsion formulations. Microemulsions have been investigated by many scientists interested in liquid state and surface physicochemistry and by many technologists foreseeing numerous applications in industry8,9. Gemini surfactants are an example of the latter approach w25 x. Solubilization of water in waterloil microemulsions continuous phase.
Critical micelle concentration and the transition point. Micellization, solubilization, and microemulsions volume 2. Reactions in micelles and micellar catalysis in aqueous media. Nonionic microemulsions as solubilizers of hydrophobic drugs. Microemulsions are very interesting systems, because the oilsurfactantwater interface forms a wide variety of structures to avoid the direct oilwater contact. Micellization, solubilization and microemulsions springerlink. Effect of ethanol on the micellization and gelation of. Percolative conduction in microemulsion type systems nature. Serajuddin novartis for example cambridge health institute issue 15. In surfactant flooding, the oil displacement generally involves the interaction among three components, that is, water, surfactant.
Initially, they were referred to as hydrophilic oleomicelles or oleophillic. Micellization, solubilization, and microemulsions springerlink. Moieties and scattering lengths est scattering moiety mol wt vol, nm3 length, cm ch2 14. Micellization, solubilization and microemulsions researchgate. Sans from tpbbased microemulsions the journal of physical chemistry, vol.
We propose here a general principle for solubilization without. In particular the microemulsions of sodium bis2ethylhexyl sulfosuccinate. Interchain distances and conformational equilibria roe1 j. They tend to form aggregates with lipids, such as micelles and. Applications of microemulsion based drug delivery system. Effects of the molecular structure of the interface and. Experimental methods of studying solubilization and factors affecting it. Micellization, solubilization, and microemulsions volume 2 k. Tween 20, 40, 60, and 80 were used separately as surfactant with methanol, ethanol, 1propanol, 1butanol or 1pentanol as cosurfactant, and ipp as oil phase to prepare various microemulsions. Design and characterization of microemulsion systems for. Micellization, solubilization and microemulsions in aqueous. Of direct relevance to this paper is an investigation of the effect of alkane type and electrolyte on the phase behavior and solubilization in nonionic microemulsions.
Micellization model and bennaimstillinger freeenergy expression stepwise association equilibrium the micellization process can be described by the ki a. The winsor 2 system is also a twophase system where a wo microemulsion coexists with an excess aqueous phase. The heavy water content is increased while the other components surfactant, cosurfactant, hydrocarbon are kept constant. Enhanced oil solubilization using microemulsions with.
Sans from tetradecyipyridinium bromide based microemuisions. The c 12 eo 5, a very common nonionic surfactant, forms extensive microemulsions with normal alkanes shinoda and friberg, 1986. Naproxen 1% was added to oil phase, then adding s cos mixture and an appropriate amount of double distilled water was added to the mixture drop by drop and the mes containing. Microemulsions based on anionic gemini surfactant pdf. In order to apply ils in pesticide microemulsions, the study of interaction between ils and surfactants is necessary. Development and evaluation of a microemulsion formulation for. Characterization of microemulsions prepared using isopropyl. Micellization and solubilization of phospholipids by surfactants. Pdf micellization, solubilization, and microemulsions, vol. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Microemulsions based on anionic gemini surfactant pdf free.
Micellization, solubilization, and microemulsions, vols. In recent years, micro emulsion drug delivery system, is a promising delivery systems which allow sustained or controlled drug release for percutaneous, peroral, topical, transdermal, ocular and parenteral administration of medicaments. The microemulsions being considered are schematically depicted in figure 1. The sizes of these structures are in the range of a few hundreds of nanometers, so the solutions are transparent. The addition of linker molecules enhances the microemulsion solubilization property, which increases the hydrophilicity andor the lipophilicity behavior of surfactants. Nagarajan department of chemical engineering, the pennsylvania state university, 161, fenske laboratory, university park, pennsylvania 16802 received may 11, 1992. Preparation of naproxen microemulsions various mes were chosen from the pseudoternary phase diagram with 4. Enhanced oil solubilization using microemulsions with linkers. The solubilization of natural phospholipids and the micellization of synthetic phospholipids as well as their comicellization by surfactants will be discussed.
Solubilization and thermal properties of microemulsions. In order to broaden the scope of the symposium, i suggested that the theme of the symposium should be micellizationy solubilization and microemulsions. Micelloobrazovanije, soljubilizacija i mikroemulsii. Qutubuddin chemical engineering department, case institute of technology, case western reserve university, cleveland, oh44106 u. The solubilization of lecithin by bile salts involves a unique mixed micellar structure that is disc shaped. Enhancing solubilization in microemulsionsstate of the art and current trends article pdf available in journal of surfactants and detergents 81. Properties and applications provides a complete and systematic assessment of all topics affecting microemulsion performance and discusses the fundamental characteristics, t. Pdf enhancing solubilization in microemulsionsstate of. Micelles, vesicles and microemulsions article pdf available in journal of the chemical society faraday transactions 2 774 january 1981 with 542 reads how we measure reads. Ionic liquids as modulators of physicochemical properties. The samples were centrifuged at 8000 rpm for 10 minutes and the drug content in the supernatant was analysed after proper dilution with methanol as described in. A comprehensive study of micellization and microemulsion formation of a cationic gemini surfactant tetramethylene1,4bisdimethyltetradecylammonium bromide.
Critical micelle concentration and the transition point for. In microemulsions, domains or droplets of one phase are dispersed in another phase, separated by a monolayer of surfactant stabilizer molecules. Tween 20, 40, 60, and 80 were used separately as surfactant with methanol, ethanol, 1. While microemulsions are used in several fields, this article focuses on the reported investigations for topical and various other applications which exhibit minimal systemic absorption. In most commercial applications involving ionic surfactants, the selection of the surfactant is based on its aqueous bulk solution properties, including its micellization characteristics and its micellar solubilization characteristics that is, the capacity of the. The microemulsions lower value of have been found to bring about an increase in the reaction rate where high 1butanol content dominates ctab1butanol reverse micelles whereas, in microemulsions higher value of, the rate constant is higher as compared to aqueous solution and the corresponding micelles but lower than that in microemulsions. Microemulsion, bicontinous, cosurfactants, lipophilic drugs, thermodynamic stability. Microemulsions offer an interesting and potentially quite powerful alternative carrier system for drug delivery because of their high solubilization capacity, transparency, thermodynamic stability, ease of preparation, and high diffusion and absorption rates when compared to solvent without the surfactant system. Bicontinuous structure zones in microemulsions nature. Micellization and solubilization of phospholipids by. Pdf micelles, vesicles and microemulsions researchgate.
The radii of these discs increase nonlinearly 20 300a with the lbs ratio and appear to diverge as the mixed micellar phase limit is approached. Kitahara and konno 11,12 systematically studied the effect of neutral electrolyte on the solubilization of aqueous phase into an oilcontinuous microemulsion. The highlight of the 1976 meeting was the illuminating presentation by dr. Emphasis will be placed on nonionic surfactants where the formation of micelles and mixed micelles with phospholipids has been well studied. Emulsifiers for pesticide microemulsions contain a part of volatile organic compounds vocs, and ionic liquids ils are becoming potential substitutes. Solubilization in nonionic microemulsions sciencedirect. Previous studies indicate the addition of a linker substance could double the solubilization of the system by segregating at the interface. Variation of interchain distances and conformational equilibria roe1 j. Design and characterization of microemulsion systems for naproxen. Micellization, solubilization, and microemulsions k l mittal haftad. This volume and its companion volume 1 chronicle the proceed ings of the international symposium on micellization, solubiliza tion, and tficroemulsions held under the auspices of the northeast regional meeting of the american chemical society in albany, new york, august.
Microemulsions have been investigated by many scientists interested in liquid state and surface physicochemistry and by many technologists foreseeing numerous applications in. Microemulsions are thermodynamically stable dispersions of oil and water stabilized by a surfactant and, in many cases, also a cosurfactant. Pdf a theory of selfassembly of surfactant molecules into micelles and bilayers is critically examined and extended to include vesicles and. Further investigation is currently performed, focusing on micellar structure and properties, and solubilization of various molecules in microemulsions and micellar systems based on the anionic gemini surfactants. Then you can start reading kindle books on your smartphone, tablet, or computer no. Importance of micelles and microemulsions in growing technological advancements. Kop micellization, solubilization, and microemulsions av k l mittal pa. October 3, 1992 we predict, qualitatively, the structural transitions in microemulsion systems induced by.
Effect of surfactants on membrane permeability with respect to drugs. Langmuir 1993,9, 369375 369 polymerinduced structural transitions in microemulsions r. Development and evaluation of a microemulsion formulation. Solubilization in microemulsions and application to separations. The widespread use of and interest in microemulsions are based mainly on the high solubilization capacity for both hydrophilic and lipophilic compounds, on their large interfacial areas, and on the ultra low interfacial tensions achieved when they coexist with excess aqueous and oil phases 2. Since palm oil and its derivatives are more polar than alkanes. Solubilization in microemulsions and application to. When surfactant molecules are dissolved in water at concentrations above the critical micelle concentration cmc, they form aggregates known as micelles. Mixing micellization solubilization and microemulsions pdf secrets for the small studio. The solubilization efficiency of paclitaxel ptx by the microemulsion was. The stability of detergentless micelles or microemulsions in such mixtures. Microemulsions this chapter is devoted to another important property of surfactants, that of stabilization of wateroil films and formation of microemulsions.
Micellization, solubilization, and microemulsions volume. Winsor iv systems 1, or microemulsions 2, are macroscopically monophasic fluid transparent compounds made up by mixing water and hydrocarbon in the presence of suitable surface active agents. The effective use of microemulsions has increased dramatically during the past few decades as major industrial applications have expanded in a variety of fields. Polymerinduced structural transitions in microemulsions. Particle size reduction leads to increase in the effective surface area resulting in enhancement of solubility and dissolution velocity of the drug. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india. Carbon nuclear magnetic resonance study of mixed micelles. Micronization technique is used to improve dissolution rates of drugs into the biological environment, in order to improve the oral bioavailability. Preparation, optimization and characterization of microemulsions microemulsions are isotropic systems, which are difficult to formulate than ordinary emulsions because their formulation is a highly specific process involving. Feb 07, 20 preparation of naproxen microemulsions various mes were chosen from the pseudoternary phase diagram with 4. Pdf the use of phase transfer catalysts with emulsion and micelle systems in electro organic synthesis.
The winsor 1 system refers to an ow microemulsion coexisting with an excess oil phase. It has been shown that the solubilization of water in microemulsions is strikingly influenced by the chemical structure of the oil and cosurfactant used. Colloids and surfaces, 29 1988 1191 119 elsevier science publishers b. How to explain microemulsions formed by solvent mixtures without. Smallangle neutron scattering is used to investigate tetradecylpyridinium bromidepentanol heptane heavy water microemulsions in the waterinoil wo microemulsion phase diagram region. Oct 17, 2014 the appellation micellization, solubilization. In order to broaden the scope of the symposium, i suggested that the theme of the symposium should be micellization. Preparation, optimization and characterization of microemulsions 169 to different oils, surfactants and cosurfactants and stirred on magnetic stirrer for 24 hours. This volume and its companion volume 1 chronicle the proceed ings of the international symposium on micellization, solubiliza tion, and tficroemulsions held under the auspices of the northeast regional meeting of the american. Recent advances in the application of solid dispersions for poorly watersoluble drugs, 2004 aaps and simonelli conference, a. It really is full of wisdom and knowledge you are going to like just how the blogger create this pdf. For p123 in 10, 20, and 30 wt % aqueous ethanol we used dynamic light scattering from dilute solutions to confirm micellization, oscillatory rheometry, and visual observation of mobility tube inversion to determine gel formation in.
501 580 1514 1420 842 823 1194 1328 377 359 1029 943 1428 1085 503 1529 653 434 1076 1246 1474 588 1333 809 1001 937 58 59 407 1497